This book contains a collection of critical reviews on the expression of biologically functional proteins in
Leishmania and
Trypanosoma,
which was written by renowned researchers on this field. Species
belonging to these trypanosomatids’ genera are etiological agents of
leishmaniasis, Chagas’ disease and sleeping sickness that are extremely
debilitating human infection diseases, which remain a major health
problem especially in countries from Latin America, Africa and Middle
East. Substantiating the problem, the currently accepted drugs for these
diseases are quiet unsatisfying due to their low efficacy and high
toxicity. In order to solve these real problems, several research groups
around the world have become involved in the study and identification
of novel potential targets in the trypanosomatid cell. Since proteins
are key macromolecules involved in crucial metabolic processes of all
living cells, studies have focused on the expression of specific
proteins produced by
Leishmania and
Trypanosoma by means
of different biochemical, molecular and proteomic approaches in order to
explore them as targets for understanding the parasite life cycle and
developing new strategies against trypanosomiasis. With these proposals
in mind, the book “Proteins and Proteomics of
Leishmania and
Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the
Leishmania and
Trypanosoma genera;
(ii) an updated review on the expression of biologically relevant
proteins by human pathogenic trypanosomatids and their possible role in
the interaction with host cells/molecules as well as a target for
development of both alternative chemotherapies and vaccine; and (iii)
several pictures, diagrams and tables that can be used to illustrate
both undergraduate and postgraduate teaching as well as scientific
lectures, being a useful resource for students and researchers.
2013
ISBN-10: 9400773048
| ISBN-13: 978-9400773042
| Edition: 2014 | PDF | 387 pages | 7.1 Mb
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