Heart disease is the leading cause of death in the Western World and heart failure following a myocardial infarction continues to increase despite urgent revascularization. Cell therapy offered the promise to reverse cardiac injury and prevent heart failure, but the initial clinical trials were not as effective as anticipated. New approaches to improve the benefits of cell therapy are urgently needed. Cardiac regeneration and repair Volume 1 reviews the pathology of cardiac injury and the latest advances in cell therapy.
Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodelling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and details their current status and future potential for cardiac therapy. Finally, part four explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell based gene therapy for cardiac regeneration.
English | 2014 | ISBN: 0857096583 | ISBN-13: 9780857096586 | 464 pages | PDF | 25,4 MB
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